Cancer Found During Routine Screening: What Happens Next

This page is for anyone who has had an abnormal cancer screening result. It walks through each step that may follow, from the callback to biopsy, the pathology report, and staging.

A screening test looks for cancer in people who have no symptoms. That is all it does. The National Cancer Institute is clear about the limit: screening tests usually do not diagnose cancer. When a result comes back abnormal, it means the test found something that needs a closer look. Nothing more.

The gap between "found something" and "found cancer" is wide. The American Cancer Society reports that fewer than 1 in 10 women called back after a screening mammogram are found to have cancer. NCI's own mammography information says plainly that most people who are called back are not found to have breast cancer. The same logic holds across screening programs. An abnormal result is a request for more information, not a verdict.

An abnormal screen is the start of a process, not the end of one.

The first step is usually a letter or a phone call asking you to come back. It may name a specific area of concern, or it may only say the images were unclear.

Breast imaging results are reported using a numbered scale. A finding described as probably benign (likely not cancer) typically leads to a repeat mammogram in about six months rather than to immediate testing. A finding described as suspicious or highly suggestive of cancer leads to a biopsy, because a biopsy is the only way to know for sure. Which category you are in changes what happens next, so it is fair to ask for the number and what it means.

A screening test and a diagnostic test can use the same machine and still be different things. Screening images are standard views taken the same way for everyone. Diagnostic images are aimed at the area in question, from more angles, sometimes magnified.

For breast findings this usually means a diagnostic mammogram, an ultrasound, or both. Other screening programs have their own next-step tests. A stool test result usually leads to colonoscopy; a lung CT finding is often re-imaged. Results of extra imaging are frequently available during the same visit, which is one of the few parts of this process that tends to be fast.

Many callbacks stop here. Additional views often show that what looked like a mass was overlapping normal tissue, or that a spot is a simple cyst.

If imaging does not settle the question, the next step is a biopsy: removing a small sample of tissue or cells to be examined under a microscope. NCI states that in most cases doctors need a biopsy to be certain that cancer is present.

Biopsies are taken with a needle, through an endoscope, or by surgery, depending on where the tissue is and how much is needed. A needle biopsy is usually done with local anesthetic and takes a short time.

This is where many people expect the answer and do not get one on the spot. The sample has to be processed and read by a specialist.

A pathologist, a doctor who studies tissue under a microscope, examines the tissue and writes a report. NCI describes that report as containing the details of your diagnosis, and notes that it also helps show which treatment options might work for you.

If the report finds no cancer, the sequence ends there, though you may be asked to return for imaging sooner than your usual interval. If the report identifies cancer, it will describe the type and how the cells look under the microscope, and that information shapes everything that follows.

You are entitled to a copy. Reports are written for clinicians, not patients, so it is reasonable to ask someone on the team to read it through with you.

Staging happens only once cancer is confirmed. NCI defines stage as the extent of the cancer, such as how large the tumor is and whether it has spread.

The most widely used system is TNM. T describes the size or extent of the tumor, N whether nearby lymph nodes are involved, and M whether the cancer has spread to distant parts of the body. Each letter is given a number or descriptor, producing a short code such as T3N1M0. Higher numbers generally mean more advanced disease.

Staging uses x-rays, lab tests, and other tests or procedures. It can add another wait, and it matters because stage guides treatment planning and clinical trial options.

The hard parts of this sequence are rarely the tests themselves. They are the gaps: between the recall letter and the appointment, between the biopsy and the pathology result, between a diagnosis and a stage.

NCI acknowledges that false-positive screening results cause anxiety and lead to follow-up testing that carries its own risks. That anxiety is a documented effect of screening, not a personal failing, and nothing about how calmly you wait changes what the report says.

A few things tend to help. Ask at each step who will call you, roughly when, and what happens if the result is delayed. Ask whether results land in your patient portal before anyone phones. Some people want to see them the moment they appear; others would rather hear them from a person first. You can say which you are, and the team can usually work with it.

• At the recall: what did the image show, and what category was the finding given?
• Before diagnostic imaging: which tests are planned today, and will I get results before I leave?
• Before a biopsy: what kind of biopsy is it, what does recovery involve, and how long until results?
• At the pathology result: can we read the report together, and can I have a copy?
• If cancer is found: what stage, which tests are still needed, and who coordinates the next appointments?
• At any point: what is the plan if this turns out to be nothing?

• Call 911 or go to an emergency department if you are vomiting blood, you pass black, tarry stools, have chest pain, or severe pain or cramping takes hold in your belly, after a colonoscopy done to follow up a screening result (MedlinePlus colonoscopy discharge; MedlinePlus GI bleeding). Do not drive yourself.
• Call your care team right away if you get chills or a fever of 100.4°F (38°C) or higher, or the number your team gave you, after that colonoscopy, vomiting will not stop, or you see red blood in your stool. MedlinePlus lists chills and fever after a colonoscopy as reasons to call, and CDC gives 100.4°F (38°C) as the fever number (MedlinePlus; CDC).
• Call your care team right away if pressure does not stop bleeding at a biopsy site, or you get a fever after a biopsy (MedlinePlus skin biopsy aftercare).
• Call your care team the same day if the skin around a biopsy site grows redder, more swollen or more painful, or leaks thick tan, green or yellow fluid (MedlinePlus skin biopsy aftercare).
• Call your care team within a day or two if the date you were told to expect a result has passed with no word, or a recall appointment cannot be booked inside the window your team named.

• https://www.cancer.gov/about-cancer/screening/patient-screening-overview-pdq
• https://www.cancer.gov/types/breast/mammograms-fact-sheet
• https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis
• https://www.cancer.gov/about-cancer/diagnosis-staging/staging
• https://www.cancer.gov/about-cancer/diagnosis-staging/understanding-lab-tests-fact-sheet
• https://www.cancer.org/cancer/types/breast-cancer/screening-tests-and-early-detection/mammograms/getting-called-back-after-a-mammogram.html
• https://medlineplus.gov/ency/patientinstructions/000897.htm
• https://medlineplus.gov/ency/article/003840.htm