The short answer
Cancer and its treatment can change your appetite and weight—some people lose weight, others gain it, and some develop malnutrition. Appetite loss often leads to eating less than your body needs. Small frequent meals, high-protein and high-calorie foods, and working with a registered dietitian can help you stay strong.
Appetite loss and weight loss are common side effects of cancer and its treatments.
Some people gain weight during treatment, often with ovarian, breast, or prostate cancer, or from steroids and hormone therapy.
Eating small meals every 2 to 3 hours and choosing high-protein, high-calorie foods can help with appetite loss.
Malnutrition is when your body doesn't get enough energy, protein, vitamins, and minerals—it can be serious.
Choose how you want to understand this
The full explanation.
Tell your team about weight changes
Whatever direction your weight goes, tell your team. A registered dietitian can help you and your family manage these changes with a plan that fits you.
Report appetite or weight problems to your doctor right away. This includes weight loss of more than 3 to 5 pounds in one week. Also tell your doctor about sudden weight gain, such as 5 pounds in a week, or weight gain that does not stop.
The simple version
Cancer and cancer treatments can change your appetite and your weight. Appetite loss and weight loss are common, but some people gain weight instead. Weight loss can lead to malnutrition, when your body does not get enough nutrients.
Appetite loss and weight loss
Anyone with cancer might lose their appetite and lose weight. It is more likely with head and neck, lung, pancreatic, or liver cancer, or cancer in the upper digestive system. Appetite loss often leads to eating less than your body needs, which leads to weight loss.
Many side effects make eating harder, including nausea and vomiting, diarrhea, constipation, feeling full quickly, painful swallowing, mouth sores, dry mouth, and taste changes. Anxiety, pain, depression, and fatigue can also reduce appetite.
Ways to manage appetite loss:
- Eat foods high in protein and calories. Eat high-protein foods first, when your appetite is strongest.
- Eat small meals every 2 to 3 hours, about 5 or 6 meals a day. Set an alarm if you forget.
- Eat within an hour of waking, and have a bedtime snack.
- Drink milkshakes, smoothies, juices, or soups if you do not feel like eating solid foods. Use whole milk or yogurt to add calories.
- Sip nutrition supplement drinks like Ensure or Boost between meals.
- Add cheese, creamy sauces, beans, or leftover meat to boost calories and protein.
- Make eating pleasant. Candles, music, and eating with loved ones can help.
If you cannot keep your appetite up, ask your doctor about appetite stimulants. These are medicines that increase appetite.
Weight gain
Although many people lose weight, you may gain weight during treatment. This is more common with ovarian, breast, or prostate cancer. Small weight changes are normal, but tell your doctor about sudden gain or gain that does not stop.
Causes of weight gain include:
- Fluid retention, from the tumor or fluid buildup.
- Increased appetite, from the cancer, treatment, or medicines.
- Metabolic changes, since hormone therapy can slow your metabolism.
- Medications, especially steroids, which increase appetite and can cause the body to hold onto water.
- Decreased activity, when fatigue and pain make it hard to move.
To manage weight gain, choose high-fiber foods, lean proteins, and low-fat dairy. Limit fat, salt, sugary drinks, and alcohol. Eat slowly and use smaller plates, and stay as active as you can. If steroids cause swelling, limiting high-sodium foods can help.
Malnutrition
Malnutrition is when your body does not get enough energy, protein, vitamins, and minerals. It can be caused by the cancer, the side effects of treatment, or both. Decreased appetite is a main cause in people with cancer. Problems with swallowing, digestion, and absorption can add to it.
Why it matters: malnutrition can make you weak and tired. It can make it harder to fight infection or finish treatment, lower your quality of life, and even become life-threatening.
Your team may use nutrition screenings to catch eating problems early. To help prevent malnutrition, eat high-calorie and high-protein foods, use supplement drinks, and eat small meals every 2 to 3 hours. If eating stays very hard, your doctor or dietitian may suggest tube feeding or IV nutrition.
Getting support
Family and friends can help with meal planning, shopping, cooking, and cleaning. Give them a list of your favorite foods. Your doctor and registered dietitian are your nutrition experts. They can help before, during, and after treatment.
For caregivers: do not be surprised if your loved one's food preferences change day to day. Offer gentle support rather than pushing them to eat, and talk through eating problems together.
When to get help sooner
- Call 911 or go to an emergency department if you cannot be roused properly, become confused, or faint after a long stretch of drinking almost nothing. If you are on chemotherapy, do the same for a temperature of 100.4°F (38°C) or higher — CDC calls a fever during chemotherapy a medical emergency, and it should not wait for a callback.
- Call your care team the same day if you cannot keep any food or fluid down for a whole day, you are passing very little urine, or pain in your mouth or throat has made drinking impossible.
- Call your care team within a day or two if you lose more than 3 to 5 pounds in one week, gain about 5 pounds in a week, or the gain keeps going. Do the same for new puffiness in your ankles or a belly that suddenly feels tight and full.
Words to know
Tap any term to see what it means.

Common questions
Why do I have no appetite during cancer treatment?
Appetite loss is a common side effect of cancer and its treatments. Side effects like nausea, vomiting, mouth sores, painful swallowing, dry mouth, taste changes, and feeling full quickly can all reduce appetite, as can anxiety, pain, depression, and fatigue.
What should I eat when I don't feel like eating?
Eat foods high in protein and calories, eat small meals every 2 to 3 hours (about 5 or 6 a day), and eat high-protein foods first when your appetite is strongest. Milkshakes, smoothies, soups, and nutrition supplement drinks like Ensure or Boost can help when you don't feel like eating solid food.
Can I gain weight during cancer treatment?
Yes. Although many people lose weight, some gain it—more commonly with ovarian, breast, or prostate cancer. Causes include fluid retention, increased appetite, metabolic changes from hormone therapy, steroids, and being less active because of fatigue or pain.
What is malnutrition and why does it matter?
Malnutrition is when your body doesn't get enough energy, protein, vitamins, and minerals. It can make you weak and tired, make it harder to fight infection or finish treatment, lower your quality of life, and even become life-threatening. Decreased appetite is a main cause in people with cancer.
When should I tell my doctor about weight changes?
Speak with your doctor right away if you start to lose weight, and report weight loss of more than 3 to 5 pounds in one week. Also tell your doctor about sudden weight gain, such as 5 pounds in a week, or weight gain that doesn't stop.
What if I can't eat enough no matter what I try?
If you continue to have trouble eating and are losing weight, your doctor or dietitian might suggest tube feeding (enteral nutrition) or IV nutrition (parenteral nutrition) to help you get the nutrients you need.
Questions to ask your doctor
Being prepared helps you get the most out of your appointments. Save or print these questions.
Tap a question to save it to your list (kept on this device).
Your next step
What needs a call today, what needs an emergency room, and what can wait.
Speak With Trained Specialists & Human Navigators
Cancer Explained provides educational guidance, but does not replace trained specialists, social workers, or your medical team.
Talk to a trained cancer information specialist
Free, confidential assistance from NCI Cancer Information Service via phone, chat, or email.
Contact your oncology team
Locate after-hours contact numbers, portal messages, or urgent triage phone lines.
Find a patient navigator
Get one-on-one help with appointments, logistics, translation, and care coordination.
Find a genetic counselor
Discuss inherited mutation risk, family history, and genetic testing options.
Find an oncology social worker
Access emotional counseling, family support groups, and mental health resources.
Find a financial navigator
Locate copay assistance foundations, grant programs, and lodging/travel support.
Find a clinical-trial specialist
Search matching studies and speak with NCI trial information specialists.
Get urgent help
Immediate emergency guidance for fever (>100.4°F during chemo), severe pain, or shortness of breath.
Help Us Improve This Guide
Did this explanation answer your question and help you determine your next step?
Know someone who needs this?
Plenty of people are looking for something like this and do not know where to start. If this would help a friend or someone you love, send it on — we have written an opening line so you do not have to stare at an empty message. You can change every word of it.
Your message is written and sent in your own email or messaging app — we never see who you send it to, and nothing is added to any list.
Knowledge Check
0 of 4 answered
This self-assessment checks understanding of educational content only. It is not medical advice.
Plain-language explanation of the published sources cited on this page. AI-assisted, source-checked, not clinician-reviewed.
Last updated: 2026-08-13Next planned review: 2027-02-03
How this page was created
Cancer Explained does not originate medical claims. Every page restates guidance already published by the National Cancer Institute, the CDC, the USPSTF and the FDA, in plain language, with the source cited so you can check the original yourself. AI does the translating and organizing; automated checks test claims, citations, clarity and safety before anything publishes. We do not employ clinicians and do not intend to — our work is translation and navigation, not clinical judgment. Nothing here is personal medical advice, and no page can account for your particular situation.
Editorial status — Source checked. This page was written with AI assistance and checked line by line against the sources listed on it. That confirms the sources support what the page says. It is not a medical review, and it does not confirm the page is complete or right for your situation.
General education — varies by person. Answers genuinely differ between people. This page explains what commonly varies and points you to your care team for your situation.
Human medical review: not completed. Pages here are not signed off by a clinician before they publish. That is not an oversight we are quietly working around: we restate published guidance and cite it, so the authority belongs to the source rather than to us, and every page names where its claims come from — you can verify us instead of trusting us. Where a volunteer clinician has reviewed a page, their name and credentials appear on it; where no name appears, no clinician has checked it. We are glad to have reviewers and are recruiting them, and we do not hold pages back waiting for one. Use this site to understand your situation and to ask better questions of the people treating you.
How this page was created
Cancer Explained does not originate medical claims. Every page restates guidance already published by the National Cancer Institute, the CDC, the USPSTF and the FDA, in plain language, with the source cited so you can check the original yourself. AI does the translating and organizing; automated checks test claims, citations, clarity and safety before anything publishes. We do not employ clinicians and do not intend to — our work is translation and navigation, not clinical judgment. Nothing here is personal medical advice, and no page can account for your particular situation.
Editorial status: Source checked — This page was written with AI assistance and checked line by line against the sources listed on it. That confirms the sources support what the page says. It is not a medical review, and it does not confirm the page is complete or right for your situation.
Human medical review: not completed. Pages here are not signed off by a clinician before they publish. That is not an oversight we are quietly working around: we restate published guidance and cite it, so the authority belongs to the source rather than to us, and every page names where its claims come from — you can verify us instead of trusting us. Where a volunteer clinician has reviewed a page, their name and credentials appear on it; where no name appears, no clinician has checked it. We are glad to have reviewers and are recruiting them, and we do not hold pages back waiting for one. Use this site to understand your situation and to ask better questions of the people treating you.
Read more about our editorial process, our use of AI, and our corrections policy.
Spotted a problem? Report an error — a factual mistake, broken or outdated source, confusing wording, or anything that seems unsafe. Please do not include names, medical record numbers, dates of birth, addresses, or other identifying medical information in your report.
After using this page, do you understand what to do next?
Anonymous — we only record the answer, never who gave it.
Related articles
Still have questions?
Educational answers, plain language
Free to print and share
