The short answer
External beam radiation therapy uses a machine to aim radiation at a specific part of the body. Most people have short treatments once a day, five days a week, for several weeks. It is painless during the session and does not make you radioactive.
External beam radiation comes from a machine that aims radiation at your cancer from outside the body.
It is a local treatment, meaning it treats only the specific part of the body with cancer.
Most people have treatment once a day, five days a week, over several weeks.
A planning session called simulation maps your treatment area, sometimes using tiny skin marks or a body mold.
Choose how you want to understand this
The full explanation.
The simple version
External beam radiation therapy comes from a machine that aims radiation at your cancer. It is a local treatment, which means it treats a specific part of your body. For example, if you have cancer in your lung, you will have radiation only to your chest, not your whole body.
It is used to treat many types of cancer.
The radiation comes from a machine outside your body and is aimed carefully at the cancer.
How it targets the cancer
There are many types of external beam radiation therapy, but they all share one goal: to deliver the highest prescribed dose of radiation to the tumor while sparing the healthy tissue around it. Each type uses a computer to study images of the tumor and calculate the most precise dose and path possible.
Some common types include 3-D conformal radiation therapy, which shapes the beams to the tumor from many directions, and intensity-modulated radiation therapy (IMRT), which uses many smaller beams and can change their strength. Image-guided radiation therapy (IGRT) uses scans during treatment to adjust for changes in the tumor's size and location. Other approaches, such as stereotactic radiosurgery, focus high-energy beams on small tumors with well-defined edges.
What happens before your first treatment
You will have a 1- to 2-hour meeting with your doctor or nurse before you begin. You will have a physical exam, talk about your medical history, and maybe have imaging tests. Your team will discuss the treatment, its benefits and side effects, and how to care for yourself. You can then choose whether to have it.
If you decide to go ahead, you will have a planning session called simulation. During simulation:
- A radiation oncologist and radiation therapist figure out your treatment area while you lie very still and have x-rays or scans.
- The therapist may tattoo or draw small dots of colored ink on your skin to mark the area. These help make sure you are in exactly the same position for every treatment. Tattooed dots are about the size of a freckle and are permanent; ink markings fade over time.
- A body mold may be made to keep you from moving during treatment. If you are getting radiation to the head and neck, you may be fitted for a mask that keeps your head still.
What a treatment session is like
Most people get external beam radiation therapy as an outpatient, meaning you do not stay overnight.
At each session, you may change into a gown, then lie on a treatment table or sit in a special chair. The room will be cool. You may see harmless colored lights that help the therapist position you. You will need to stay very still so the radiation goes to the exact same place each time. The radiation itself takes about 1 to 5 minutes, and you can breathe normally.
The radiation therapist leaves the room just before treatment begins and controls the machine from nearby. They watch you on a screen or through a window and talk with you through a speaker. Tell them if you feel sick or uncomfortable — they can stop the machine at any time. You will hear and see the machine move, but you will not feel, hear, see, or smell the radiation. Most visits last 30 minutes to an hour, with most of that time spent getting you into position.
How often and for how long
Most people have treatment once a day, five days a week, Monday through Friday. Radiation is given in a series of treatments to let healthy cells recover and to make the radiation more effective. The span from your first treatment to your last is called a course of treatment. How many weeks you need depends on the type of cancer, the goal of treatment, the radiation dose, and the schedule.
It will not make you radioactive
People often wonder if they will be radioactive during treatment. External beam radiation therapy will not make you radioactive. You may safely be around other people, even pregnant women, babies, and young children.
When to get help sooner
Radiation itself is painless, but the treated area needs watching between sessions.
- Call your care team the same day if the treated skin blisters, weeps, or opens into a raw sore. NCI calls this a moist reaction, and it can get infected if it is left.
- Get seen the same hour, not the same day, if your temperature reaches 100.4°F (38°C) or higher, or you get shaking chills. MedlinePlus is clear that an infection during cancer treatment is an emergency, so use your team's urgent number or go to an emergency department, and do not take a fever-reducing medicine first unless your team has told you to.
- Call your care team the same day if you are having radiation to the chest or throat and swallowing has become too painful to drink, or you cannot keep fluids down. Dehydration is the usual reason a course gets interrupted.
- Call your care team within a day or two if the skin turns red, dark, itchy, swollen, flaky or crusty, or if new diarrhea, urinary burning or headaches start. Also call if you are struggling to get to appointments. Departments would far rather rearrange transport than lose sessions.
Words to know
Tap any term to see what it means.

Common questions
What is external beam radiation therapy?
External beam radiation therapy comes from a machine that aims radiation at your cancer. It is a local treatment, which means it treats a specific part of your body. For example, if you have lung cancer, you would have radiation only to your chest, not your whole body.
How often will I have treatment?
Most people have external beam radiation therapy once a day, five days a week, Monday through Friday. Radiation is given in a series of treatments to allow healthy cells to recover and to make the radiation more effective. How many weeks depends on your cancer, the goal of treatment, and the radiation dose and schedule.
What happens at the planning session?
Before treatment you have a session called simulation. A radiation oncologist and radiation therapist map your treatment area while you lie still and have x-rays or scans. They may make small ink marks or tattoos on your skin, and sometimes a body mold or face mask is made to help you stay in the same position each time.
Does radiation therapy hurt during the session?
You will not feel, hear, see, or smell the radiation. You lie still for about 1 to 5 minutes while the machine delivers treatment, and you can breathe normally. Most visits last 30 minutes to an hour, with most of that time spent placing you in the correct position.
Will external beam radiation make me radioactive?
No. External beam radiation therapy will not make you radioactive. You may safely be around other people, including pregnant women, babies, and young children.
What should I wear to treatment?
Wear comfortable clothes made of soft fabric that are easy to take off, since you may need to expose the treatment area or change into a gown. Avoid tight clothing near the treatment area, and do not wear jewelry, adhesive bandages, or powder there.
Questions to ask your doctor
Being prepared helps you get the most out of your appointments. Save or print these questions.
Tap a question to save it to your list (kept on this device).
Speak With Trained Specialists & Human Navigators
Cancer Explained provides educational guidance, but does not replace trained specialists, social workers, or your medical team.
Talk to a trained cancer information specialist
Free, confidential assistance from NCI Cancer Information Service via phone, chat, or email.
Contact your oncology team
Locate after-hours contact numbers, portal messages, or urgent triage phone lines.
Find a patient navigator
Get one-on-one help with appointments, logistics, translation, and care coordination.
Find a genetic counselor
Discuss inherited mutation risk, family history, and genetic testing options.
Find an oncology social worker
Access emotional counseling, family support groups, and mental health resources.
Find a financial navigator
Locate copay assistance foundations, grant programs, and lodging/travel support.
Find a clinical-trial specialist
Search matching studies and speak with NCI trial information specialists.
Get urgent help
Immediate emergency guidance for fever (>100.4°F during chemo), severe pain, or shortness of breath.
Help Us Improve This Guide
Did this explanation answer your question and help you determine your next step?
Know someone who needs this?
Plenty of people are looking for something like this and do not know where to start. If this would help a friend or someone you love, send it on — we have written an opening line so you do not have to stare at an empty message. You can change every word of it.
Your message is written and sent in your own email or messaging app — we never see who you send it to, and nothing is added to any list.
Knowledge Check
0 of 4 answered
This self-assessment checks understanding of educational content only. It is not medical advice.
Plain-language explanation of the published sources cited on this page. AI-assisted, source-checked, not clinician-reviewed.
Sources last checked: 2026-08-13 what this meansLast updated: 2026-08-13Next planned review: 2027-01-14
How this page was created
Cancer Explained does not originate medical claims. Every page restates guidance already published by the National Cancer Institute, the CDC, the USPSTF and the FDA, in plain language, with the source cited so you can check the original yourself. AI does the translating and organizing; automated checks test claims, citations, clarity and safety before anything publishes. We do not employ clinicians and do not intend to — our work is translation and navigation, not clinical judgment. Nothing here is personal medical advice, and no page can account for your particular situation.
Editorial status — Source checked. This page was written with AI assistance and checked line by line against the sources listed on it. That confirms the sources support what the page says. It is not a medical review, and it does not confirm the page is complete or right for your situation.
General education — varies by person. Answers genuinely differ between people. This page explains what commonly varies and points you to your care team for your situation.
Human medical review: not completed. Pages here are not signed off by a clinician before they publish. That is not an oversight we are quietly working around: we restate published guidance and cite it, so the authority belongs to the source rather than to us, and every page names where its claims come from — you can verify us instead of trusting us. Where a volunteer clinician has reviewed a page, their name and credentials appear on it; where no name appears, no clinician has checked it. We are glad to have reviewers and are recruiting them, and we do not hold pages back waiting for one. Use this site to understand your situation and to ask better questions of the people treating you.
How this page was created
Cancer Explained does not originate medical claims. Every page restates guidance already published by the National Cancer Institute, the CDC, the USPSTF and the FDA, in plain language, with the source cited so you can check the original yourself. AI does the translating and organizing; automated checks test claims, citations, clarity and safety before anything publishes. We do not employ clinicians and do not intend to — our work is translation and navigation, not clinical judgment. Nothing here is personal medical advice, and no page can account for your particular situation.
Editorial status: Source checked — This page was written with AI assistance and checked line by line against the sources listed on it. That confirms the sources support what the page says. It is not a medical review, and it does not confirm the page is complete or right for your situation.
Human medical review: not completed. Pages here are not signed off by a clinician before they publish. That is not an oversight we are quietly working around: we restate published guidance and cite it, so the authority belongs to the source rather than to us, and every page names where its claims come from — you can verify us instead of trusting us. Where a volunteer clinician has reviewed a page, their name and credentials appear on it; where no name appears, no clinician has checked it. We are glad to have reviewers and are recruiting them, and we do not hold pages back waiting for one. Use this site to understand your situation and to ask better questions of the people treating you.
Read more about our editorial process, our use of AI, and our corrections policy.
Spotted a problem? Report an error — a factual mistake, broken or outdated source, confusing wording, or anything that seems unsafe. Please do not include names, medical record numbers, dates of birth, addresses, or other identifying medical information in your report.
After using this page, do you understand what to do next?
Anonymous — we only record the answer, never who gave it.
Related articles
Still have questions?
Educational answers, plain language
Free to print and share
