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Benzene at oil refineries and cancer risk

Benzene occurs in crude oil and is used in making gasoline. NCI says benzene exposure increases the risk of leukemia and other blood disorders.

NCI source:NCI last reviewed 2024-08-06

Review status: AI-assisted, source checked. Not reviewed by a clinician. How we check pages

The short answer

Benzene is a chemical found naturally in crude oil and used in gasoline production, so refinery work brings people close to it. NCI states that exposure to benzene increases the risk of developing leukemia and other blood disorders. For the general population the biggest single source is not industry at all — it is cigarette smoke.

  • Benzene is a colourless or light-yellow liquid at room temperature, present naturally in crude oil and used as a solvent and in making gasoline.

  • NCI states that exposure to benzene increases the risk of developing leukemia and other blood disorders.

  • Industrial workers in manufacturing and chemical facilities are among those exposed on the job.

  • Mainstream cigarette smoke accounts for about half of total benzene exposure in the U.S. population.

Choose how you want to read this

The whole article, with every detail and caution.

This page is for refinery workers, past and present, and the people close to them. It looks at what NCI says about benzene, where most exposure really comes from, and what steps make sense.

Why refineries come up in this conversation

Benzene is not something a company chose to add to petroleum. The National Cancer Institute says it occurs naturally in crude oil. It is used in making gasoline. It is also a widely used industrial solvent.

Because benzene is in crude oil and used in gasoline production, refinery work can bring people near it. NCI points to CDC for how to protect yourself at work.

What NCI says about the harm

The core statement is short. Exposure to benzene raises the risk of leukemia and other blood disorders.

Leukemia is cancer of the blood-forming tissue. That includes the bone marrow, where blood cells are made. That is why the harm NCI describes shows up in the blood.

Who is exposed, and how much

NCI describes exposure through several routes:

  • industrial workers in manufacturing and chemical plants
  • gasoline fumes and motor vehicle exhaust
  • glues, adhesives, cleaning products, and paint strippers
  • natural sources, including volcanic activity and forest fires

NCI says industrial workers face the highest occupational levels of benzene.

The comparison almost nobody expects

Here is the number that changes how this topic looks. NCI reports that mainstream cigarette smoke accounts for about half of total benzene exposure in the U.S. population. And among people who smoke, 90 percent of their benzene exposure comes from smoking.

NCI's figures are about the whole U.S. population and about people who smoke. They do not measure any one workplace. They are not a reason to relax about exposure at work. They do show that for someone who smokes, smoking is the largest benzene source NCI describes, so quitting matters.

Reducing exposure

NCI's advice is practical. Avoid smoking and secondhand tobacco smoke. Limit contact with gasoline fumes. For protection at work, NCI points to CDC resources. That is the right place for job-specific detail.

For job-specific protection, see the CDC information NCI links to. Your employer or occupational health service can explain the controls used at your site.

Sensible steps for someone with this work history

Ask your employer or occupational health service whether exposure monitoring results are available for your work area. This advice is not from NCI.

Get your job history into your medical record. Note the years, the sites, and the roles. A doctor treating you in twenty years will not know unless it is written down.

Take the smoking question seriously, however tired you are of hearing it. Given NCI's figures above, smoking is a major source of benzene for people who smoke.

Report unexplained bruising. Report unusual tiredness, repeated infections, or bleeding that seems out of proportion. These have many ordinary causes, and they rarely turn out to be serious. But they are worth mentioning rather than sitting on. That is especially true with this exposure history behind you.

Talking about it at home

Families of refinery workers sometimes ask whether anything gets carried home. This page cannot answer that for one plant. The honest response is to point at the people who can. That means the site occupational health service, and the union or safety representative. Both will know the specific processes involved.

Try to avoid the two extremes. Do not brush the question aside. And do not treat every shift as a hazard. Neither view matches how exposure really works in a controlled industrial setting.

A welder wearing a protective helmet and gloves works on metal with a glowing tungsten arc
Welding with protective gear. Photo: U.S. Air Force (Public domain), via Wikimedia Commons.

Common questions

Which cancer is benzene linked to?

NCI's statement is that benzene exposure increases the risk of developing leukemia and other blood disorders. Leukemia is a cancer of the blood-forming tissue.

I work at a refinery. Am I certain to be harmed?

No. NCI says benzene exposure increases risk. That is a statement about risk, not a prediction for any one person. Ask your occupational health service about protections at your site.

Where else does benzene come from?

NCI lists gasoline fumes and motor vehicle exhaust, and products such as glues, adhesives, cleaning products and paint strippers. It also occurs naturally from volcanoes and forest fires.

What is the single biggest source for most people?

Cigarette smoke. NCI states that mainstream cigarette smoke accounts for about half of total U.S. population exposure, and 90 percent of exposure among people who smoke.

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Written from National Cancer Institute material and compared with the source cited below.

Plain-language explanation of the published sources cited on this page. AI-assisted, source-checked, not clinician-reviewed.

Sources last checked: 2026-08-11 what this meansLast updated: 2026-10-02Next planned review: 2027-08-11

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Cancer Explained does not originate medical claims. Every page restates guidance already published by the National Cancer Institute, the CDC, the USPSTF and the FDA, in plain language, with the source cited so you can check the original yourself. AI does the translating and organizing; automated checks test claims, citations, clarity and safety before anything publishes, and this is translation and navigation, not clinical judgment. Nothing here is personal medical advice, and no page can account for your particular situation.

Editorial status: Source checked — This page was written with AI assistance and then compared with the sources listed on it, looking for statements those sources do not back up. That check is not a sentence-by-sentence record and can miss errors. It is not a medical review, and it does not confirm the page is complete or right for your situation.

Human medical review: not completed. Pages here are not signed off by a clinician before they publish. That is not an oversight we are quietly working around: we restate published guidance and cite it, so the authority belongs to the source rather than to us, and every page names where its claims come from — you can verify us instead of trusting us. Where a volunteer clinician has reviewed a page, their name and credentials appear on it; where no name appears, no clinician has checked it. We are glad to have reviewers and are recruiting them, and we do not hold pages back waiting for one. Use this site to understand your situation and to ask better questions of the people treating you.

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