The short answer
The V Foundation for Cancer Research was founded in 1993 by ESPN and college basketball coach Jim Valvano, who was dying of cancer at the time. It funds high-risk, high-reward cancer research and says it has awarded more than $500 million across nearly 1,500 grants, directing 100% of direct donations to research. It funds science; it does not treat patients or run clinical trials itself.
The V Foundation was founded in 1993 by ESPN and Jim Valvano, a college basketball coach who was terminally ill with cancer.
Valvano delivered his famous 'Don't Give Up... Don't Ever Give Up' speech at the 1993 ESPY Awards, where he received the Arthur Ashe Courage Award.
The foundation funds high-risk, high-reward cancer research at National Cancer Institute-designated centers and other leading institutions in the U.S. and Canada.
The V Foundation reports awarding more than $500 million across nearly 1,500 grants since its founding.
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Born from a speech at the ESPYs
The V Foundation for Cancer Research began in 1993. ESPN and Jim Valvano founded it jointly. Valvano was a college basketball coach, best known for leading North Carolina State to the 1983 national championship. By 1993, Valvano was terminally ill with cancer.
On March 4, 1993, at the ESPY Awards, Valvano received the Arthur Ashe Courage Award. His acceptance speech became one of the most quoted moments in sports history. He told the audience the work "may save my children's lives. It may save someone you love." He delivered the line the foundation still uses as its rallying cry: "Don't Give Up... Don't Ever Give Up!" The V Foundation was created that same year. It was built directly out of that call for more cancer research funding.
What kind of research it funds
The V Foundation's stated mission is to fund "high-risk, high-reward research projects for all types of cancer from the best and brightest scientists." That phrase matters. High-risk, high-reward research means backing ideas that might not pan out. But they could lead to major breakthroughs if they do. This is a category that can struggle to get funded through more careful, conservative grant channels.
Grants go to scientists at National Cancer Institute-designated cancer centers. They also go to other leading research institutions across the United States and Canada. The foundation is not itself a hospital or research lab. It is a funding body. It channels donations toward researchers working at other institutions.
A specific promise about where the money goes
The V Foundation states that 100% of direct donations go to cancer research. It says this is possible because a separate endowment covers the organization's administrative costs. So money given by individual donors is not reduced by overhead before it reaches research grants. This is a specific structural claim. It is distinct from a general statement about "efficiency." It is part of why the foundation has drawn attention among fundraising organizations for how it allocates money.
The scale of its funding record
The V Foundation reports awarding more than $500 million across nearly 1,500 grants since its 1993 founding. It also reports that researchers it has funded have gone on to participate in approximately 1,100 clinical trials over their careers. Those researchers have attracted an additional $22 billion in cancer research funding from other sources. In the organization's telling, V Foundation grants often serve as early funding that helps researchers secure larger grants later. The foundation connects this research investment to a broader trend: 18.6 million cancer survivors currently living in the U.S. But that national survivor figure reflects many factors beyond any single funder's work.
The organization has also reported 14 consecutive four-star ratings from Charity Navigator.
What the V Foundation can do
For a patient or family, the V Foundation's most direct relevance is as a funding source. It backs research that may eventually shape new treatments. That could include research related to a person's own specific cancer type, since its grants cover all types of cancer rather than one disease area. Public events like its Wine Celebration and annual Gala are among the ways it raises the donations that fund this research.
What the V Foundation cannot do
The V Foundation does not treat patients, diagnose cancer, or run its own hospital or clinic. It does not manage clinical trials directly. Those are conducted at the institutions where its funded researchers work. Funding a "high-risk, high-reward" research project also does not guarantee that project will succeed or lead to a usable treatment. That is the nature of the research category the foundation specifically set out to support.
A large lifetime grant total, like the reported $500 million, reflects decades of cumulative giving across many separate projects. It is not a single fund available to any one patient. For an individual seeking a specific new treatment or trial, the V Foundation is a funder behind the science. It is not a place to apply for personal treatment support.
Why the history still resonates
Jim Valvano's ESPY speech remains one of the most direct public calls for cancer research funding ever delivered on television. The V Foundation was created that same year, which gives its founding an unusually documented, public origin. More than three decades later, its funding record still stands. So does its structural promise that all direct donations go to research. That is why it remains a frequently cited name in cancer research philanthropy.

Common questions
Who founded the V Foundation, and when?
The V Foundation for Cancer Research was founded in 1993 by ESPN and Jim Valvano, a college basketball coach who was terminally ill with cancer at the time.
What was Jim Valvano's ESPY speech about?
At the 1993 ESPY Awards on March 4, Valvano accepted the Arthur Ashe Courage Award and delivered a speech that included the line 'Don't Give Up... Don't Ever Give Up,' calling for greater investment in cancer research.
What kind of research does the V Foundation fund?
It funds what it describes as high-risk, high-reward research projects covering all types of cancer, carried out by scientists at National Cancer Institute-designated cancer centers and other leading research institutions in the U.S. and Canada.
Does the V Foundation treat cancer patients?
No. The V Foundation is a research-funding organization. It does not treat patients, run hospitals, or manage clinical trials on its own, though researchers it funds have gone on to participate in clinical trials at their own institutions.
How much has the V Foundation given to cancer research?
The foundation reports awarding more than $500 million across nearly 1,500 grants since its founding in 1993.
Why does the V Foundation say 100% of donations go to research?
The organization states that its administrative costs are covered by a separate endowment, which it says allows all direct donations to be applied to cancer research grants rather than overhead.
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Cancer Explained does not originate medical claims. Every page restates guidance already published by the National Cancer Institute, the CDC, the USPSTF and the FDA, in plain language, with the source cited so you can check the original yourself. AI does the translating and organizing; automated checks test claims, citations, clarity and safety before anything publishes, and this is translation and navigation, not clinical judgment. Nothing here is personal medical advice, and no page can account for your particular situation.
Editorial status: Editorial review complete — This page completed Cancer Explained's editorial checks (sources, safety, plain language, duplication). It has not been reviewed by a physician or other healthcare professional.
Human medical review: not completed. Pages here are not signed off by a clinician before they publish. That is not an oversight we are quietly working around: we restate published guidance and cite it, so the authority belongs to the source rather than to us, and every page names where its claims come from — you can verify us instead of trusting us. Where a volunteer clinician has reviewed a page, their name and credentials appear on it; where no name appears, no clinician has checked it. We are glad to have reviewers and are recruiting them, and we do not hold pages back waiting for one. Use this site to understand your situation and to ask better questions of the people treating you.
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