The Last Lecture: pancreatic cancer with no screening test

This page is for readers deciding whether to read The Last Lecture, including people facing cancer and those who love them. It describes the book, then explains what is known about finding pancreatic cancer early.

In September 2007 Randy Pausch, a computer science professor at Carnegie Mellon University, gave a talk called "Really Achieving Your Childhood Dreams." He had been diagnosed with pancreatic cancer the year before, had surgery, and had recently learned the cancer was in his liver. He had been told he had months.

The talk was filmed and spread widely. Pausch then worked with the Wall Street Journal writer Jeffrey Zaslow to turn it into a book. It was published by Hyperion in April 2008 and runs to about 224 pages.

Spoilers, and a plain fact up front. Randy Pausch died on 25 July 2008, a few months after publication. The book does not treat this as a twist. He says early and repeatedly that he is dying, and the whole structure depends on it.

It is important to be clear about what kind of book this is. It is not a cancer memoir in the sense that The Undying or It's Always Something are cancer memoirs. Pausch is not writing about scans, drug names or clinics. He is writing a set of instructions for living. They are addressed in the first instance to his three young children, who he feared would not remember him.

The book is short and made of very short pieces. Most chapters run two or three pages, some barely a page. They are grouped into titled sections that follow the shape of the original lecture rather than a chronology of illness.

The opening section explains the occasion. Carnegie Mellon has a "last lecture" tradition, in which a professor speaks as though it were their final talk. For Pausch it more or less was. He describes deciding to give it, and the argument with his wife about whether the time would be better spent at home.

The middle sections work through the childhood ambitions that gave the lecture its title. These include being in zero gravity, writing an article for the World Book Encyclopedia, and working at Disney. He says what each attempt taught him.

Then comes a run of chapters on enabling other people's dreams, mostly drawn from teaching. One is the head fake, where students learn something serious while thinking they are making animations. Another is the brick wall that is there to show how badly you want something.

The last stretch turns domestic and blunt. Chapters on time as a finite resource, on apologising properly, on his marriage, and on the practical business of leaving. There is very little medical narration anywhere in it. The cancer is the reason for the book, not its content.

There is no appendix, no glossary, no list of resources, and no bibliography. The book does not present itself as a guide, and it should not be used as one.

It is honest about motive. Pausch says outright that the lecture was a way of putting himself in a bottle for his children. The audience in the hall was, in a sense, incidental. That is a truer account of why dying people make things than most books of this kind manage.

It is good on time. Once a prognosis is measured in months, the ordinary calculations about what to spend a Tuesday on stop working. His chapters on that are specific and unsentimental.

It is good on other people. A large part of the book is about students, colleagues and mentors, and about the specific ways adults either open doors for younger people or quietly close them. That material has nothing to do with cancer and is the part most readers remember years later.

It is also short. That matters. Many people who have just been given bad news cannot read a long book, and this one can be read in pieces of five minutes.

The optimism is real, and it is his. It is not a claim about outcomes, and it should not be read as one. Pausch was clear that his attitude did not alter his prognosis. Books like this can nonetheless leave readers feeling that the right frame of mind is a duty.

The treatment detail is thin and now dated. It reflects one man's care in 2006 to 2008 and should not be used to understand current pancreatic cancer treatment. NCI's current patient summary is the place for that.

It is also, unavoidably, the story of a person with a stable job and health insurance through a university. He also had a supportive employer and a public platform. Readers whose experience of cancer is mostly an experience of bills and phone calls with insurers may find the book's world unrecognisable.

One more caution about how the book is used. It has been widely given as a gift to people who have just been diagnosed, often by people who have not read it closely. Handed over that way, it can read as an instruction to be inspiring. That comes at a point when someone is mostly trying to get through the week. A book is not a treatment plan, and nobody owes anyone a good attitude.

Pausch's cancer was found after symptoms, which is the ordinary route. NCI states that pancreatic cancer does not have early signs or symptoms, which makes it very hard to detect in its early stages. NCI also notes that the pancreas lies behind the lower part of the stomach.

NCI lists several symptoms. They are abdominal and back discomfort, jaundice (yellowing of the skin and eyes, with pale stools, dark urine and itching), unexplained weight loss, reduced appetite and tiredness. It also lists digestive problems such as gas, bloating, nausea and vomiting, and leg swelling. New-onset diabetes and blood clots can also be associated. NCI adds plainly that these symptoms can also be caused by other, less serious conditions. If you have them, see a doctor.

On risk, NCI separates what can be changed from what cannot. Tobacco use, alcohol and body weight sit in the first group. Age, family history and certain inherited conditions including Lynch syndrome sit in the second. NCI's own caution is worth repeating: having one or more of these risk factors does not necessarily mean you will get pancreatic cancer.

NCI's general symptoms guidance sets the threshold for acting. If symptoms do not get better after a few weeks, see a doctor. NCI adds that cancer often causes no pain, so pain is not the signal to wait for. For more on the individual signs, see pancreatic cancer symptoms and the general list at symptoms of cancer.

Readers often finish this book asking why nobody caught it sooner. The honest answer is that for someone at average risk, there was nothing to catch it with.

The US Preventive Services Task Force recommends against screening for pancreatic cancer in asymptomatic adults. This is a D grade, reaffirmed in 2019. A D grade means the Task Force found that the harms outweigh any benefit at population level. The disease is uncommon enough that most abnormal findings in a screened population would be false alarms, and follow-up of a pancreatic finding is not trivial.

That recommendation explicitly does not cover people with inherited genetic syndromes or familial pancreatic cancer. Those situations are managed individually, and are a conversation with a genetics service rather than a routine test. What counts as high enough risk, and what surveillance is offered, is decided case by case with a care team.

It is also worth separating screening from diagnosis. A screening test is offered to people with no symptoms, in the hope of finding disease early. The scans and biopsies that follow a symptom are diagnostic tests. The fact that no screening programme exists does not mean nothing can be done once something is wrong. Anyone with symptoms like those above should see a doctor promptly rather than wait.

So the gap the book sits in is real. Pancreatic cancer combines quiet early disease with no average-risk screening test. That is why symptom awareness carries the whole weight. For the wider picture of which cancers do have tests, see cancer screening, and for risk see pancreatic cancer risk factors.

One more federal point the book never raises. NCI states that palliative care may be provided at any point during cancer care, from diagnosis to the end of life, alongside treatment. It adds that some studies show integrating it soon after a diagnosis of advanced cancer can improve quality of life and mood. Pausch's book is full of the work of dying well without ever naming the service designed to help with it.

Pausch had pancreatic cancer. There is still no screening test for it for people at ordinary risk.

It suits someone with young children who is trying to work out what to leave behind. It also suits someone who wants a short book they can put down. It suits teachers.

It does not suit a reader who wants to understand pancreatic cancer, because it does not try to explain it. It may not suit someone who is angry, or frightened, or broke, and who does not want to be told about brick walls this week. That is a reasonable reaction and not a failure of nerve.

• The Last Lecture — edition record, ISBN 9781401323257 (Open Library)
• NCI — Pancreatic Cancer Treatment (PDQ) Patient Version
• USPSTF — Pancreatic Cancer: Screening
• NCI — Symptoms of Cancer
• NCI — Palliative Care in Cancer

This page discusses The Last Lecture for education. It is not medical advice, and nothing here is a judgement of anyone's real medical care.