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Disponible en español: La depresión y el cáncer

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Depression and Cancer

Depression is more than ordinary sadness, and it is a common but treatable condition in people with cancer. Learn the signs to watch for and how it is treated. Based on National Cancer Institute resources.

AI-assisted and source verified. Not reviewed by a healthcare professional unless specifically stated.

Sources last checked: 2026-07-14Last updated: 2026-07-14Next planned review: 2028-07-13

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Cancer Explained uses AI to organize and translate information from the authoritative sources cited on each page. Automated checks review claims, citations, clarity, duplication, and potential safety concerns before publication. Our content is not currently reviewed by physicians unless a specific qualified reviewer is named on the page. Cancer Explained provides general education and should not replace advice from your healthcare team.

Editorial status — Source verified. This page was created with AI assistance and checked against the sources listed on it. Source checking is not a medical review.

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NCI source

National Cancer Institute

The short answer

Depression is different from normal sadness. It is a medical condition marked by ongoing sadness, low energy, and trouble with daily life. About 2 in 10 people with cancer become depressed, and depression can be treated with talk therapy, medicine, or both. If signs last more than 2 weeks, tell your health care team.

  • Depression is more than normal sadness; it is a treatable medical condition.

  • About 2 out of every 10 people diagnosed with cancer become depressed.

  • If signs of depression last more than 2 weeks, talk to your doctor.

  • Talk therapy, physical activity, and medicine can all help treat depression.

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The full explanation.

Depression is different from normal sadness

Depression is more than feeling down or sad from time to time. It is a medical problem marked by ongoing feelings of sadness, despair, loss of energy, and difficulty dealing with daily life. If you have these feelings most of the day for longer than 2 weeks, it may be a sign of depression.

Other signs of depression include:

  • loss of pleasure and interest in activities you used to enjoy
  • changes in eating and sleeping habits
  • slow physical and mental responses
  • feeling restless or jittery
  • unexplained tiredness
  • feeling worthless, hopeless, or helpless
  • feeling a lot of guilt for no reason
  • trouble paying attention
  • frequent thoughts of death

People diagnosed with cancer may also feel disbelief or denial, worry about the future, or grief. Symptoms are not the same for every person.

How common it is

About 2 out of every 10 people diagnosed with cancer become depressed. The number of men and women affected is about the same. Not everyone reacts to cancer the same way, so some people may not have depression at all, while others may have major depression.

A cancer diagnosis brings many stressful issues, such as facing your mortality, changes in life plans, changes in body image, and worry about money. Cancer-related fatigue, pain, and a weaker physical condition can also raise the risk. But having a personal history of mental health issues or a lack of social support are even more important factors.

Signs can have physical causes too

It is important to know that some signs of depression can be caused by physical problems. Certain medical conditions can lead to depression in people with cancer, such as pain that does not go away with treatment, abnormal levels of certain minerals in the blood, too little vitamin B12 or folate, anemia, thyroid problems, poor sleep, and side effects from certain drugs.

Because of this, it helps to talk about your symptoms with your doctor. Your provider may ask about your feelings, your moods, and how long your symptoms have lasted. They may also do a physical exam or run lab tests to rule out other causes.

Depression can be treated

Help is available, and depression can be treated. The decision to treat depends on how long it has lasted and how much it affects your life. You may have depression that needs treatment if you are not able to do your usual activities, have severe symptoms, or the symptoms do not go away. Treatment may include talk therapy, medicine, or both.

Counseling or talk therapy

Talk therapy helps some people with depression. Your doctor may suggest you see a psychologist or psychiatrist. Most programs are offered in both individual and small-group settings. A therapy program can help you learn:

  • coping and problem-solving skills
  • relaxation skills and ways to lower stress
  • ways to change negative thoughts
  • more about cancer and its treatment

Talking with a clergy member may also help some people.

Physical activity

Being physically active may help relieve depression and its symptoms. At least 150 minutes of moderate-to-vigorous exercise per week has been shown to reduce depression in breast cancer survivors. Ask your doctor what level of activity is safe for you.

Medicine

Antidepressants help some people. When you take them, it is important to do so under the care of a doctor. Some antidepressants take 3 to 6 weeks to work. Because you may take several drugs during cancer care, tell your health care team about all your medicines, herbals, and supplements, so they can help prevent unwanted reactions.

A note about safety

Some people with cancer feel hopeless at times and think about suicide. If you feel hopeless, talk with your doctor, because there are ways they can help.

If you or someone you know is thinking about suicide, get help as soon as possible. Dial 911 in an emergency, or call, text, or chat 988 to reach the 988 Suicide and Crisis Lifeline. Counselors are available 24 hours a day, 7 days a week, including for people who are deaf or hard of hearing.

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Common questions

How is depression different from normal sadness?

Depression is more than feeling down or sad from time to time. It is a medical problem marked by ongoing sadness, loss of energy, and trouble dealing with daily life. If you have these feelings most of the day for longer than 2 weeks, it may be a sign of depression.

How common is depression in people with cancer?

About 2 out of every 10 people diagnosed with cancer become depressed. The number of men and women affected is about the same. Not everyone diagnosed with cancer reacts the same way, and some people do not have depression at all.

What are some signs of depression to watch for?

Signs include lasting sadness, loss of interest in activities you used to enjoy, changes in eating or sleeping, unexplained tiredness, feeling worthless or hopeless, trouble concentrating, and frequent thoughts of death. If these last more than 2 weeks, talk to your doctor.

Can depression during cancer be treated?

Yes. Help is available. The decision to treat depends on how long it has lasted and how much it affects your life. Treatment may include talk therapy, medicine, or both. Being physically active may also help relieve symptoms.

Could my symptoms be caused by something other than depression?

Sometimes. Some symptoms of depression can be due to physical problems, and side effects of drugs or the cancer itself can seem like depression. That is why it is important to talk about your symptoms with your doctor, who may do an exam or lab tests.

What should I do if I have thoughts of suicide?

Get help right away. Dial 911 in an emergency, or call, text, or chat 988 to reach the 988 Suicide and Crisis Lifeline. Counselors are available 24 hours a day, 7 days a week, including for people who are deaf or hard of hearing.

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0 of 4 answered

  1. Q1.According to this article, how is depression different from normal sadness?
  2. Q2.About how many people diagnosed with cancer become depressed, according to the article?
  3. Q3.How long should signs of depression last before you talk to your doctor, according to the article?
  4. Q4.Which of these is a way depression during cancer can be treated, according to the article?

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How this page was created

Cancer Explained uses AI to organize and translate information from the authoritative sources cited on each page. Automated checks review claims, citations, clarity, duplication, and potential safety concerns before publication. Our content is not currently reviewed by physicians unless a specific qualified reviewer is named on the page. Cancer Explained provides general education and should not replace advice from your healthcare team.

Editorial status: Source verified This page was created with AI assistance and checked against the sources listed on it. Source checking is not a medical review.

Human medical review: not completed. At this time, most Cancer Explained content has not been reviewed by a physician or other healthcare professional. Pages with documented human medical review identify the reviewer, credentials, and review date directly.

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