What does a variant of uncertain significance mean?

A variant of uncertain significance, or VUS, is a gene change for which there is not yet enough data to know whether it raises cancer risk. It is one of the possible results of genetic testing for inherited cancer risk.

According to the National Cancer Institute, most often a VUS is later reclassified as benign, meaning it does not raise risk. Because a VUS is not known to be harmful, it is typically not used to make health care decisions. Instead, decisions are based on a person's personal and family history and other risk factors.

If you have a VUS result, it is important to stay in touch with the provider who ordered the test. New information may lead the variant to be reclassified in the future, and your provider can let you know if that happens. A genetic counselor can help explain what a VUS means for you.