Skip to main content
Cancer Explained
Beginner 4 min read Verified

Bone Cancer in Children: Osteosarcoma and Ewing Sarcoma

A plain-language explanation of the two main bone cancers in children and teens — osteosarcoma and Ewing sarcoma — and how they are treated. Based on the National Cancer Institute.

NCI source

Last reviewed: 2026-07-07

The short answer

The two main bone cancers in children and teens are osteosarcoma and Ewing sarcoma. Both often cause bone pain and swelling, frequently near the knee or in the long bones. Treatment usually combines chemotherapy with surgery, and sometimes radiation for Ewing sarcoma.

  • The two main childhood bone cancers are osteosarcoma and Ewing sarcoma.

  • They most often affect older children and teenagers.

  • Common symptoms are bone pain and swelling, often near the knee or in the long bones.

  • Osteosarcoma usually starts in the bone itself; Ewing sarcoma can start in bone or nearby soft tissue.

Choose how you want to understand this

The full explanation.

The simple version

The two main bone cancers in children and teens are osteosarcoma and Ewing sarcoma. Both most often affect older children and teenagers and frequently cause bone pain and swelling.

Two main types

The two types start in slightly different places:

  • Osteosarcoma — the most common childhood bone cancer; usually starts in the bone itself, often near the ends of long bones like around the knee
  • Ewing sarcoma — can start in a bone or in the soft tissue around it

Symptoms

The most common symptoms are bone pain and swelling, often near the knee or in the long bones of the arms and legs. Pain may be worse at night or with activity, and a bone weakened by a tumor can sometimes break.

How they are treated

Treatment usually combines chemotherapy with surgery to remove the tumor. Radiation therapy is sometimes used for Ewing sarcoma. Whenever possible, surgeons use limb-sparing surgery to remove the tumor while saving the arm or leg.

Limb-sparing surgery can often remove the tumor while saving the affected limb.

Words to know

Tap any term to see what it means.

Browse the full glossary →

Common questions

What are the main bone cancers in children?

The two main types are osteosarcoma and Ewing sarcoma. Both most often affect older children and teenagers.

What are the symptoms?

The most common symptoms are bone pain and swelling, often near the knee or in the long bones of the arms and legs. Pain may be worse at night or with activity.

How are osteosarcoma and Ewing sarcoma different?

Osteosarcoma usually starts in the bone itself, most often near the ends of long bones. Ewing sarcoma can start in a bone or in the soft tissue around it.

How are they treated?

Treatment usually combines chemotherapy with surgery to remove the tumor. Radiation therapy is sometimes used for Ewing sarcoma. Limb-sparing surgery is often possible.

What is limb-sparing surgery?

It is surgery that removes the tumor while saving the arm or leg, often using a bone graft or an implant to replace the removed bone.

Questions to ask your doctor

Being prepared helps you get the most out of your appointments. Save or print these questions.

Open my question list

Tap a question to save it to your list (kept on this device).

Quick quiz

Test your knowledge

0 of 4 answered

  1. Q1.What are the two main bone cancers in children and teens?
  2. Q2.What are common symptoms?
  3. Q3.What is limb-sparing surgery?
  4. Q4.Which cancer sometimes also uses radiation therapy?

This quiz checks understanding of educational content only. It is not medical advice. Open this quiz on its own page.

Related learning map

How this explanation connects to 10 other things you can explore — related topics, terms, questions, practice, and its NCI source.

Bone Cancer in Children: Osteosarcoma and Ewing Sarcoma