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Cancer Explained
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Melanoma: Signs and Symptoms

A plain-language guide to the warning signs of melanoma, the most serious skin cancer, using the ABCDE rule. Based on the National Cancer Institute.

NCI source

Last reviewed: 2026-07-07

The short answer

Melanoma often shows up as a new or changing mole. The ABCDE rule — Asymmetry, Border, Color, Diameter, Evolving — helps spot warning signs. Found early, melanoma is very treatable.

  • Melanoma often appears as a new mole or a change in an existing mole.

  • The ABCDE rule helps: Asymmetry, Border, Color, Diameter, Evolving.

  • A spot that looks different from your others (the 'ugly duckling') is worth checking.

  • Melanoma can also appear as a sore that does not heal or a dark streak under a nail.

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The full explanation.

The simple version

Melanoma is the most serious type of skin cancer, but it is very treatable when found early. It often shows up as a new mole or a change in an existing one, so knowing the warning signs helps you catch it early.

The ABCDE rule

Watch for these signs in a mole:

  • A — Asymmetry: one half does not match the other
  • B — Border: ragged or irregular edges
  • C — Color: more than one shade or uneven color
  • D — Diameter: larger than a pencil eraser
  • E — Evolving: changing in size, shape, or color

The ugly duckling

Another helpful clue is the 'ugly duckling' sign: a spot that looks different from your other moles. A mole that stands out from the rest is worth checking, even if it does not meet every ABCDE sign.

A mole that is changing, or that looks different from your others, should be checked.

When to see a doctor

See a doctor or dermatologist for any new or changing mole, a spot that stands out, a sore that does not heal, or a dark streak under a nail. Early melanoma is very treatable.

Words to know

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Common questions

What does melanoma look like?

It often appears as a new mole or a change in an existing one. The ABCDE rule describes warning signs: Asymmetry, irregular Border, uneven Color, large Diameter, and Evolving (changing over time).

What is the 'ugly duckling' sign?

It is a spot that looks different from your other moles. A mole that stands out from the rest is worth having checked, even if it does not meet every ABCDE sign.

Where can melanoma appear?

It can appear anywhere, including areas with little sun exposure, and sometimes as a dark streak under a nail or a sore that does not heal.

Is melanoma treatable?

Yes, especially when found early. Early melanoma is very treatable, which is why checking new or changing spots matters.

Questions to ask your doctor

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  1. Q1.What does the ABCDE rule help spot?
  2. Q2.What is the 'ugly duckling' sign?
  3. Q3.Is early melanoma treatable?

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Melanoma: Signs and Symptoms